Find our new findings on microtubule processing during rhizobial infection by a nanodomain localized DREPP protein as a bioRxiv pre-preprint.
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New Preprint on proximity labelling in plants
We are happy to share results we obtained in a multi-effort approach together with the labs of Daniel Van Damme (VIB Ghent, Belgium), Panos Moschou (Uppsala BioCenter, Sweden) and Geert De Jaeger (VIB Ghent, Belgium). We demonstrate robust functionality of proximity-dependent biotin labelling in plants.
You can find the pdf version of the manuscript here.
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New Transmission electron microscope (TEM) funded
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New paper on regulation of nodulation
Work from a collaboration with Xia Li’s lab at Huazhong Agricultural University (China) has just been published online in Molecular Plant. Congratulations to Xia’s team and Chao Su from our lab!
Here, we report that the microRNA172c (miR172c) activates soybean (Glycine max) Rhizobia-Induced CLE1 (GmRIC1) and GmRIC2 by removing the transcriptional repression of these genes by soybean Nodule Number Control 1 (NNC1), thereby activating the AON pathway. NNC1 interacts with GmNINa, the soybean ortholog of Lotus NODULE INCEPTION (NIN) and hampers its transcriptional activation of GmRIC1 and GmRIC2. Importantly, GmNINa acts as a transcriptional activator of miR172c. Intriguingly, NNC1 can transcriptionally repress miR172c expression, introducing a novel negative feedback loop into the NNC1 regulatory network. Moreover, GmNINa interacts with NNC1 and can relieve the NNC1-mediated repression of miR172c transcription. Thus, the GmNINa/miR172c/NNC1 network is a master switch that coordinately regulates and optimizes NF and AON signaling, supporting the balance between nodulation and AON in soybean.
Molecular Plant (2019); https://doi.org/10.1016/j.molp.2019.06.002
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From our TEM unit: How to polarize archaea?
New contribution from our TEM unit.
Our EM unit headed by Marta Rodriguez-Franco contributed to a new paper from Sonja Albers’ lab. In the current study, they show that cells of haloarchaea are polarized. The cellular positioning of proteins involved in chemotaxis and motility is spatially and temporally organized in these cells. This suggests the presence of a specific mechanism responsible for the positioning of macromolecular protein complexes in archaea.
Positioning of the Motility Machinery in Halophilic Archaea.
Li Z, Kinosita Y, Rodriguez-Franco M, Nußbaum P, Braun F, Delpech F,
Quax TEF, Albers SV.
MBio. 2019 May 7;10(3). pii: e00377-19. doi: 10.1128/mBio.00377-19. -
Pengbo talks at the MPMI congress in Glasgow
Pengbo’s abstract entititled “The SYFO-mediated cell wall- plasma membrane- cytoskeleton continuum is required for symbiotic infections in Medicago truncatula” has been selected for oral presentation at the MPMI congress 2019 in Glasgow. He will talk in Concurrent Session 16: Cell Biology of Host-Microbe Interactions I. Congratulations Pengbo and thanks to the organizers for selecting.
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Seminar (June 28): Mary Williams (Featured Editor of The Plant Cell)
We are happy to host Featured editor of The Plant Cell Mary Williams for a seminar on “Why and how to engage with the public about science” and a scientific writing workshop on June 27-28, 2019. Mary joined The Plant Cell in 2009 where she developed Teaching Tools in Plant Biology. She also contributes to the Plantae network as an editor and mentor.
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Seminar (June 7): Yoselin Benitez-Alfonso (Leeds, UK)
We are happy to host Yoselin Benetitez-Alfonso from the University of Leeds on 6.-7. June 2019 at our institute and learn more about her exciting working on callose and plasmodesmata and their role in transcellular signaling. She will give a seminar on 7. June at 10:15 am in room SR 0.043 on “The role of callose and cell walls on the regulation of symplastic intercellular signalling and symbiosis“. Find out more about her work on: https://benitezalfonso.wordpress.com/
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Chao wins Poster Prize
Our PhD student Chao Su won the prize for the best poster at the iMMM2019 in Torino. Congratulations! Well done and deserved!
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Our work in CIBSS
Our work in frame of the newly funded excellence cluster ‘Centre for Integrative Biological Signalling Studies‘ (CIBSS) was just highlighted in the online magazine of the University of Freiburg. If you are interested, read the full article.
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PhD position available
Applications are invited for a Ph.D. position to join the Group of Marco Trujillo at the University of Freiburg.
Research in the Trujillo lab (www.trujillolab.com) focuses on understanding ubiquitin signalling and its roles in the regulation of immune responses and general protein homeostasis. Previous and ongoing research in the Lab has uncovered key roles of ubiquitination in the regulation intracellular vesicle transport and its interplay with signalling stemming from receptor kinases.
The Project
Newly synthesized membrane proteins are delivered to the plasma membrane in a highly specific and regulated manner through the secretory pathway. In this joint project with the laboratory of Thomas Ott (University of Freiburg; https://plantcellbiology.net), the successful candidate will work on elucidating regulatory mechanisms governing the secretory activity. The project encompasses a multidisciplinary approach combining biochemistry (structural biology, protein-protein & protein-lipid interaction analyses, enzyme activity assays, mass-spectrometry), and cell biology (CLSM, TIRF/VAEM).
This is an exciting opportunity for the applicant to join a multi-disciplinary research group within an international centre of excellence in sciences.
The ideal candidate
We are looking for a highly motivated individual with experience in protein biochemistry and cell biology. The successful candidate will possess a Master in Science (full award) in protein biochemistry or a related discipline. Can take initiative, function well in a team, and have a hands-on mentality, perseverance and critical mind-set. Proficiency in English language for both oral and written communication.
Reviewing of applications will start February 1st 2019 and continue until position is filled. The position is available immediately.
Additional Information
The position is funded by the DFG for three years. Salary will be according to the German Public Sector Agreement (E13, 65%) commensurate to qualifications and experience.
Please include for your application: Cover letter detailing your motivation and background for applying for the position, CV, copy of PhD degree, name and address of three referees.
For further information and details, please contact Marco Trujillo directly marco.trujillo@bio.uni-freiburg.de .
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EMBO course on Electron Microscopy
Registration is open for the EMBO course “Advanced methods of electron microscopy in cell biology” held between 10-20 June 2019 in České Budějovice, Czech Republic. We are also happy to announce that the head of our Electron Microscopy Facility, Marta Rodriguez-Franco, will be teaching there as well. Don’t miss to register and get inspired there. Check it out at
http://meetings.embo.org/event/19-advanced-em
