The initial proposal for the “Centre for Integrative Biological Signalling Studies” (CIBSS) has been successful in the first round of the national Excellence Strategy 2017. This competition is headed by the German Research Foundation (Deutsche Forschungsgemeinschaft; DFG) and aims to identify novel and innovative local clusters. CIBSS will study signalling across different spatial and temporal scales by understanding mechanisms on the molecular level. This should be translated into specific control of function approaches. Congratulations for this important first step to the CIBSS team but also to the Freiburg livMatS cluster.